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Image Search Results
Journal: British Journal of Cancer
Article Title: Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts
doi: 10.1038/bjc.2016.383
Figure Lengend Snippet: ( A ) Hh gene expression in cervical cancer xenografts. The qRT-PCR data sets (mean±s.e.) for OCICx models 29, 30, 34 and ME180 are shown for human and mouse Hh genes: IHH, SHH, SMO, PTCH1, PTCH2, GLi1. Data sets were normalised against the L32 housekeeping gene. ( B ) The per cent stroma levels as defined by Spectrum Genie Aperio analysis with H&E representative images for the 3 OCICx and ME180 tumours.
Article Snippet: 5E1, a monoclonal antibody for
Techniques: Gene Expression, Quantitative RT-PCR
Journal: British Journal of Cancer
Article Title: Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts
doi: 10.1038/bjc.2016.383
Figure Lengend Snippet: Hh gene expression in ME180 orthotopic cervix tumours treated with Hh inhibitors: 5E1 and LDE225. 5E1 was administered weekly for 21 days in treatment (20 mg kg i.p subcutaneously). The LDE225 was administered daily for 7 days (60 mg kg by oral gavage). The qRT-PCR data set (mean±s.e. with 4–5 mice per group) for human IHH, SHH, SMO, PTCH1, PTCH2, GLi1 is shown. Data sets were normalised against the L32 housekeeping gene. Treatment was started at Day 9 post implant at tumour size of 4–5 mm. Hh expression levels with 5E1 and LDE225 treatment show significance relative to control. P <0.05.
Article Snippet: 5E1, a monoclonal antibody for
Techniques: Gene Expression, Quantitative RT-PCR, Expressing, Control